There has been significant research on the cardiovascular benefits of L-arginine – the primary ingredient in Perfusia-SR – for supporting vascular health and blood flow. One of L-arginine's most important roles is as a biological precursor of nitric oxide. The vascular endothelium (the lining of the arteries) creates nitric oxide from L-arginine, resulting primarily in blood vessel relaxation. This property is important to maintaining good vascular health, heart health, reproductive health, wound healing, and protection against oxidative damage. L-arginine also promotes increased work capacity during exercise, supports lean muscle mass, and helps erections occur in the normal course of intimacy. Perfusia-SR is provided in a sustained-release formula to maintain an optimal level of L-arginine over 24 hours with suggested twice-daily use.