Clinical studies demonstrate that berberine supports healthy lipid metabolism and cholesterol homeostasis. Berberine can activate an important metabolic enzyme known as adenosine monophosphate-activated protein kinase (AMPK), a central regulator of cellular energy homeostasis. Mechanistic research in vitro and in vivo suggests that berberine can decrease cholesterol and triglyceride synthesis by activating AMPK.
In addition to supporting lipid metabolism, berberine supports healthy glucose metabolism and blood sugar management already within a normal range. Mechanistic research in vitro suggests that berberine can support healthy glucose regulation through promoting glucose uptake in cells via GLUT4 translocation.