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NAG is a metabolic jumping-off point for a complex, enzyme-regulated polymerization process that generates glycosaminoglycans (GAG), which in turn become further organized into cartilage, bone, ligaments, tendons, sclera, and other specialized connective tissues. GAG are major structural contributors to the basement membranes of the skin and internal epithelia, the intima of the blood vessels, the heart valves, and the lens and sclera of the eye, as well as synovial fluid and the linings of the joints.