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DHEA (Dehydroepiandrosterone) is an androgen (male sex hormone). DHEA is two steps down from pregnenolone in the steroid synthesis pathway. Pregnenolone is first converted to 17-OH Pregnenolone and then to DHEA. DHEA may also be synthesized in the brain. It is the most common adrenal steroid hormone in the body, and it is a precursor for both testosterone and estrogen.